New depression gene isolated
New research into the genetic basis of the depression has localized a gene, called RNF123, which may play a role in major depression.
The new study, led by David Glahn, Ph.D., of Yale University sought to lay out a “big picture” of the genetic contribution to depression by combining disparate, yet relevant types of genetic information.
“They have provided a very exciting strategy for uniting the various types of data that we collect in clinical research in studies attempting to identify risk genes,” said Dr. John Krystal, Editor of Biological Psychiatry.
Researchers set out with two clear goals: to describe a new method for ranking measures of brain structure and function on their genetic importance for an illness, and then to localize a candidate gene for major depression.
“We were trying to come up with a way that could generally be used to link biological measurements to (psychiatric) disease risk,” said geneticist John Blangero, Ph.D., director of the AT&T Genomics Computing Center at the Texas Biomedical Research Institute. “And in our first application of this, in relation to major depressive disorder, we’ve actually come up with something quite exciting.”
While RNF123 hasn’t previously been linked to depression, it has been shown to affect a part of the brain called the hippocampus, which has been found to be altered in people with major depression.
“We assume that the biological measures are closer mechanistically to the underlying disease processes in the brain. Yet, ultimately we are interested in the subjective experiences and functional impairment associated with mental illness,” added Krystal.
“The approach employed in this study may help to make use of all of this information, hopefully increasing our ability to identify genes that cause depression or might be targeted for its treatment.”
Glahn said, “We still have more work before we truly believe this is a home-run gene, but we’ve got a really good candidate. Even that has been tough to do in depression.”
Source: Elsevier
“High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes” by David C. Glahn, Joanne E. Curran, Anderson M. Winkler, Melanie A. Carless, Jack W. Kent Jr., Jac C. Charlesworth, Matthew P. Johnson, Harald H.H. Göring, Shelley A. Cole, Thomas D. Dyer, Eric K. Moses, Rene L. Olvera, Peter Kochunov, Ravi Duggirala, Peter T. Fox, Laura Almasy, John and Blangero (doi: 10.1016/j.biopsych.2011.08.022). The article appears in Biological Psychiatry, Volume 71, Issue 1 (January 1, 2012), published by Elsevier.
